Anti-IGF1R/CD221 抗体说明书

Anti-IGF1R/CD221抗体说明书

 Anti-IGF1R/CD221抗体说明书

Cat.Number: Rs-0227RQuantitysize: 0.1ml （dilutewithpH7.4   0.01MPBSordiluentofantibody） Background:Thisreceptorbindsinsulin-likegrowthfactor1（IGF1）withahighaffinityandIGF2withaloweraffinity.Ithasatyrosine-proteinkinaseactivity,whichisnecessaryfortheactivationoftheIGF1-stimulateddownstreamsigna领cascade.WhenpresentinahybridreceptorwithINSR,bindsIGF1.PubMed:12138094showsthathybridreceptorscomposedofIGF1RandINSRisoformLongareactivatedwithahighaffinitybyIGF1,withlowaffinitybyIGF2andnotsignificantlyactivatedbyinsulin,andthathybridreceptorscomposedofIGF1RandINSRisoformShortareactivatedbyIGF1,IGF2andinsulin.Incontrast,PubMed:16831875showsthathybridreceptorscomposedofIGF1RandINSRisoformLongandhybridreceptorscomposedofIGF1RandINSRisoformShorthavesimilarbindingcharacteristics,bothbindIGF1andhavealowaffinityforinsulin. 

 Anti-IGF1R/CD221抗体说明书

Specificity:     ·anti-CD221isarabbitmonoclonalantibodyunconjugated               ·specificforCD221of hu,ratandmo                ·epitopemappingneartheaminoterminusofCD221of                    hu,ratandmoorigin               ·useforwesternblotting,elisa,immunoprecipitation                      andimmunohistochemistry· ProteinAaffinitychromatographypurification,purity:>95%·Isotype:IgG·molwt:82kDa Application:    ·Westernblotting:1:100-500·Immunohistochemistry:1:100-500·ELISA:1:500-1000· Optimalworkingdilutionsmustbedeterminedbytheenduser. Storage:  Storeat–20ºCforoneyear.Avoidrepeatedfreeze/thawcycles.Thelyophilizedantibodyisstableatroomtemperatureforatleastonemonthandforgreaterthanayearwhenkeptat-20ºC.WhenreconstitutedinsterilepH7.40.01MPBSordiluentofantibodytheantibodyisstableforatleasttwoweeksat2-4ºC. ImportantNote: Thisproductassuppliedis intendedforresearchuseonly,notforuseinhuman,therapeuticordiagnosticapplications.

 Anti-IGF1R/CD221抗体说明书

  
2004-07-13