仪器资讯
Anti-IntegrinαVβ3抗体说明书
Quantitysize: 0.1ml （dilutewithpH7.4 0.01MPBSordiluentofantibody）
Background:Integrinsareintegralcell-surfaceproteinscomposedofanalphachainandabetachain.Theyareknowntoparticipateincelladhesionaswellascell-surfacemediatedsignal领.Integrinsareheterodimericintegralmembraneproteinscomposedofanalphachainandabetachain.CD51encodesintegrinalphachainV.TheI-domaincontainingintegrinalphaVundergoespost-translationalcleavagetoyielddisulfide-linkedheavyandlightchains,thatcombinewithmultipleintegrinbetachainstoformdifferentintegrins.TheCD61proteinproductistheintegrinbetachainbeta3.Integrinbeta3isfoundalongwiththealphaIIbchaininplatelets.IntegrinalphaV/beta3isareceptorforcytotactin,fibronectin,laminin,matrixmetalloproteinase2,osteopontin,osteomodulin,prothrombin,thrombospondin,vitronectinandvonWillebrandfactor.IntegrinalphaV/beta3recognizesthesequenceR-G-Dinawidearrayofligands.ThealphaVintegrinsarereceptorsforvitronectin,cytotactin,fibronectin,fibrinogen,laminin,matrixmetalloproteinase2,osteopontin,osteomodulin,prothrombin,thrombospondinandvonWillebrandfactor.TheyrecognizethesequenceR-G-Dinawidearrayofligands. Anti-IntegrinαVβ3抗体说明书Specificity: ·anti-IntegrinαVβ3isarabbitmonoclonalantibodyunconjugated ·specificforIntegrinαVβ3ofhuman ·epitopemappingneartheaminoterminusofIntegrinαVβ3of ratorigin ·useforwesternblotting,elisa,immunoprecipitation andimmunohistochemistry· ProteinAaffinitychromatographypurification,purity:>95%·Isotype:IgG·molwt:82kDa Application: ·Westernblotting:1:100-500·Immunohistochemistry:1:100-500·ELISA:1:500-1000· Optimalworkingdilutionsmustbedeterminedbytheenduser. Storage: Storeat–20ºCforoneyear.Avoidrepeatedfreeze/thawcycles.Thelyophilizedantibodyisstableatroomtemperatureforatleastonemonthandforgreaterthanayearwhenkeptat-20ºC.WhenreconstitutedinsterilepH7.40.01MPBSordiluentofantibodytheantibodyisstableforatleasttwoweeksat2-4ºC. ImportantNote: Thisproductassuppliedis intendedforresearchuseonly,notforuseinhuman,therapeuticordiagnosticapplications.Anti-IntegrinαVβ3抗体说明书
