Anti-desmin/FITC抗体说明书-仪器网
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Anti-desmin/FITC抗体说明书

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Anti-desmin/FITC抗体说明书 

CatalogNumber:RSF-1026R 

Quantitysize:0.1ml(2mg/ml;Reconstitutewith0.5mlofsteriledistilledwater.)

Background:

filamentsfoundinmusclecells.InadultstriatedmuscletheyformafibrousnetworkconnectingmyofibrilstoeachotherandtotheplasmamembranefromtheperipheryoftheZlinestructures.DefectsinDesminarethecauseofdesminrelatedcardioskeletalmyopathy(CSM)alsoknownasdesminrelatedmyopathy(DRM).CSMischaracterizedbyskeletalmuscleweaknessassociatedwithcardiacconductionblocks,arrhythmias,restrictiveheartfailure,andbyintracytoplasmicaccumulationofdesminreactivedepositsincardiacandskeletalmusclecells.Adesminrelatedmyopathycanhaveadistalonset,itisthenknownashereditarydistalmyopathy(HDM).DefectsinDesminarealsothecauseofdilatedcardiomyopathytype1I(CMD1I).CMD1Iisanautosomalformofdilatedcardiomyopathycharacterizedbyventriculardilatationandimpairedsystolicfunction.Antidesminantibodiesareusefulinidentificationoftumoursofmyogenicorigin.Specificity:

·anti-desmin isarabbitpolyclonalantibody,FITCconjugated

·specificfordesminofhuman,mouseandrat

·epitopemappingneartheaminoterminusofdesminofhuman,

mouseratorigin

·human,mouse,rat crossreacted

·affinitychromatographypurification,purity:>95%

·Isotype:IgG

·molwt:25kDa

Application:

·FCM:1:20-100

·Immunohistochemistry:1:20-200

·Immunofluorescence:1:20-200

·Excitationspectrum:490-495nm

·Emissionspectrum:520-530nm

·Optimalworkingdilutionsmustbedeterminedbytheenduser.

Storage:Storeat–20ºCforoneyear.Avoidrepeatedfreeze/thawcycles.Thelyophilizedantibodyisstableatroomtemperatureforatleastonemonthandforgreaterthanayearwhenkeptat-20ºC.WhenreconstitutedinsterilepH7.40.01MPBSordiluentofantibody,theantibodyisstableforatleasttwoweeksat2-4ºC.

ImportantNote:Thisproductassuppliedisintendedforresearchuseonly,notforuseinhuman,therapeuticordiagnosticapplications.

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2004-07-13
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