四倍体期鼠胚胎干细胞杂交技术方法

Hybrid Embryonic Stem Cell-Derived Tetraploid Mice Show
Apparently Normal Morphological, Physiological, and
Neurological Characteristics
Frieder Schwenk,1 Branko Zevnik,1 Jens Bru¨ning,2 MathiasRo¨hl,2Antje Willuweit,1
Anja Rode,1 Thomas Hennek,1 Gunther Kauselmann,1RudolfJaenisch,3
and Ralf Ku¨hn1*
Artemis Pharmaceuticals GmbH1 and Klinik II und Poliklinikfu¨rInnere Medizin der Universita¨t Ko¨ln and
Center of Molecular Medicine,2 Cologne, Germany, andWhiteheadInstitute for Biomedical Research and
Department of Biology, Massachusetts Institute ofTechnology,Cambridge, Massachusetts3 胚胎聚集针 胚胎聚集针