(水凝胶弹簧圈栓塞)缠绕密度对脑动脉瘤流体力学特性的影

Over the past 15 years, coil embolization has
emerged as an effective treatment option for cerebral
aneurysms that is far less invasive than the long-standing
convention of surgical clipping. However, aneurysm recurrence
after coil embolization is not uncommon: recurrence
rates as high as 50% have been reported in the literature. One
factor that may contribute to recurrence after coi领 is
residual flow into the aneurysmal sac. At present, there is
limited quantitative knowledge of the relationship between
coil packing density and aneurysmal inflow. We present an
in vitro fluid dynamic study of basilar tip aneurysm models
that elucidates this relationship. At physiologically normal
flow rates, we found that a packing density of 28.4%
decreased aneurysmal inflow by 31.6% in a wide-neck model,
and that a packing density of 36.5% decreased aneurysmal
inflow by 49.6% in a narrow-neck model. Results also
indicated that coi领 reduced aneurysmal inflow more
significantly at lower parent vessel flow rates, and that
coi领 reduced neck-plane velocity magnitudes more significantly
for narrow-neck aneurysms. Our study provides novel
quantitative information that could ultimately contribute to
improved outcomes for patients with cerebral aneurysms by
enab领 more effective coil embolization. 德国LaVision PIV/PLIF粒子成像测速场仪 Imager sCMOS PIV相机 用于粒子成像测速(PIV)的荧光示踪粒子