支架构型对脑动脉瘤流体力学特性的影响研究

Embolic coi领 is the most popular endovascular treatment available for cerebral aneurysms. Nevertheless,
the embolic coi领 of wide-neck aneurysms is challenging and, in many cases, ineffective. Use
of highly porous stents to support coi领 of wide-neck aneurysms has become a common procedure in
recent years. Several studies have also demonstrated that high porosity stents alone can significantly
alter aneurysmal hemodynamics, but differences among different stent configurations have not been
fully characterized. As a result, it is usually unclear which stent configuration is optimal for treatment.
In this paper, we present a flow study that elucidates the influence of stent configuration on cerebral
aneurysm fluid dynamics in an idealized wide-neck basilar tip aneurysm model. Aneurysmal fluid
dynamics for three different stent configurations (half-Y, Y and, cross-bar) were first quantified using
particle image velocimetry and then compared. Computational fluid dynamics (CFD) simulations were
also conducted for selected stent configurations to facilitate validation and provide more detailed
characterizations of the fluid dynamics promoted by different stent configurations. In vitro results
showed that the Y stent configuration reduced cross-neck flow most significantly, while the cross-bar
configuration reduced velocity magnitudes within the aneurysmal sac most significantly. The half-Y
configuration led to increased velocity magnitudes within the aneurysmal sac at high parent-vessel
flow rates. Experimental results were in strong agreement with CFD simulations. Simulated results
indicated that differences in fluid dynamic performance among the different stent configurations can be
attributed primarily to protruding struts within the bifurcation region. 德国LaVision PIV/PLIF粒子成像测速场仪 三维立体PIV