激光散斑成像系统(激光多普勒扫描成像系统)利用多普勒原理,通过光频谱分析获得血流分布图,具有实时成像且分辨率高的特点,适合对多种组织器官进行点式或线式的快速扫描。
可以对组织血流进行连续监测,用于记录由于皮肤营养和体温调节等因素引起的毛细血管,微静脉和微动脉中的血流变化,如脑皮质血流、海马血流、肠系膜血流、肝血流、肾血流、血流等各组织血流量、流速、组织血氧测定。广泛应用于临床研究和科研实验室。
型号:OZ-2/OZ-3
性能介绍:
· 非接触:图像由低功率激光扫描组织获得。患者与扫描仪之间距离ZD1m;
· 日间操作:独特的光学设计,即使在室内环境光线很强时也能操作;
· 重复扫描模式:可对进行性反应成像,并通过自动分析功能定量;
· 彩色数码相机简化扫描设置,并提供扫描区域的照片;
· 高分辨率高达256x256个
· 独立检测:分辨率为0.2~2.0mm/像素
· 还可提供0.1mm/像素的高分辨率型号;
· 灵活的扫描尺寸,从1像素到50cmx50cm的任意矩形;
· 界面友好的软件,数据库记录并存储了患者资料和图像信息非常容易进入和进行搜索;
· 双波长/高分辨率版本可供选择;
激光多普勒血流仪的测试原理图:
主要技术参数:
· 激光光源:单波长系统,近红外780nm或830nm,红光635nm-690nm,2.5mW,光束1.0mm,IEC 60825-1:2001标准3R级;
· CCD相机:自动聚焦,电动10倍光学变焦,752x582像素分辨率;
· 带宽:取决于扫描速度:低通(3db) 20Hz、100Hz或250Hz;
可选高通(0.1db)3Khz、15Khz或22.5Khz;
· 范围和扫面区域:距离20cm,ZD面积为13cmx13cm;距离100cm,ZD面积为50cmx50cm.
· 扫描速度:约4ms/像素,10ms/像素或50ms/像素;
· 典型成像速度为20秒完成15cmx15cm图像在64x64像素分辨率;
· 5分钟内完成50cmx50cm,图像在256x256像素分辨率;
· 空间分辨率:ZD256x256像素:20cm处0.2mm/像素的“常规扫描”,10cm处2.0mm/像素的“大点扫描”
· 照明条件:正常环境照明;
· 软件:基于Windows™的控制;
· 处理和分析软件支架:移动支架、桌面支架;
· 电压:接受84-264V交流电,50VA,50-60Hz
· 控制器:尺寸W H D mm 305 x 115 x 260;重量4.5kgs.
· 扫描头:尺寸W H D mm 426 x 244 x 300;重量8kgs.
· 存放温度:0-45℃.
· 使用温度:15-30℃.
胃部血流实例图:
胃部血流实例图:
文献参考:
1.Tomita I, Kume S, Sugahara S, et al. SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Body-Induced mTORC1 Inhibition. Cell Metab. 2020;32(3):404-419.e6. doi:10.1016/j.cmet.2020.06.020
2.Krawetz RJ, Abubacker S, Leonard C, et al. Proteoglycan 4 (PRG4) treatment enhances wound closure and tissue regeneration. NPJ Regen Med. 2022;7(1):32. doi:10.1038/s41536-022-00228-5.
3.Sugimoto K, Nomura S, Shirao S, et al. Cilostazol decreases duration of spreading depolarization and spreading ischemia after aneurysmal subarachnoid hemorrhage. Ann Neurol. 2018;84(6):873-885. doi:10.1002/ana.25361.
4.Choi W, Key J, Youn I, et al. Cavitation-assisted sonothrombolysis by asymmetrical nanostars
for accelerated thrombolysis. J Control Release. 2022;350:870-885. doi:10.1016/j.jconrel.2022.09.008.
5.Takashima M, Nakamura K, Kiyohara T, et al. Low-dose sodium-glucose cotransporter 2 inhibitor ameliorates ischemic brain injury in mice through pericyte protection without glucose-lowering effects. Commun Biol. 2022;5(1):653. doi:10.1038/s42003-022-03605-4.
6.Lecordier S, Pons V, Rivest S, et al. Multifocal Cerebral Microinfarcts Modulate Early Alzheimer's Disease Pathology in a Sex-Dependent Manner. Front Immunol. 2022;12:813536. doi:10.3389/fimmu.2021.813536.
7.Deng Y, Ohgami N, Kagawa T, et al. Vascular endothelium as a target tissue for short-term exposure to low-frequency noise that increases cutaneous blood flow. Sci Total Environ. 2022;851(Pt 1):158828. doi:10.1016/j.scitotenv.2022.158828.
8.Lee D, Nakai A, Miwa Y, et al. Retinal Degeneration in a Murine Model of Retinal Ischemia by Unilateral Common Carotid Artery Occlusion. Biomed Res Int. 2021;2021:7727648. doi:10.1155/2021/7727648.
9.Shimizu T, Terawaki K, Sekiguchi K, et al. Tokishakuyakusan ameliorates lowered body temperature after immersion in cold water through the early recovery of blood flow in rats. J Ethnopharmacol. 2022;285:114896. doi:10.1016/j.jep.2021.114896.
10.Kobayashi H, Zha X, Nagase K, et al. Phosphodiesterase 5 inhibitor suppresses prostate weight increase in type 2 diabetic rats. Life Sci. 2022;298:120504. doi:10.1016/j.lfs.2022.120504.
11.Yamamoto H, Okada M. Sympathetic ganglionectomy for facial blushing using application of laser speckle flow graph. J Thorac Cardiovasc Surg. 2018;156(3):1326-1331. doi:10.1016/j.jtcvs.2017.12.147.
12.Majima T, Matsukawa Y, Funahashi Y, et al. The effect of mirabegron on bladder blood flow in a rat model of bladder outlet obstruction. World J Urol. 2020;38(8):2021-2027. doi:10.1007/s00345-019-02939-9.
13.Mizuno Y, Taguchi T. A hydrophobic gelatin fiber sheet promotes secretion of endogenous vascular endothelial growth factor and stimulates angiogenesis. RSC Adv. 2020;10(42):24800-24807. doi:10.1039/d0ra03593a.
14.Shibahara T, Ago T, Nakamura K, et al. Pericyte-Mediated Tissue Repair through PDGFRβ Promotes Peri-Infarct Astrogliosis, Oligodendrogenesis, and Functional Recovery after Acute Ischemic Stroke. eNeuro. 2020;7(2):ENEURO.0474-19.2020. doi:10.1523/ENEURO.0474-19.2020.
15.Ramakrishna K, Singh N, Krishnamurthy S. Diindolylmethane ameliorates platelet aggregation and thrombosis: In silico, in vitro, and in vivo studies. Eur J Pharmacol. 2022;919:174812. doi:10.1016/j.ejphar.2022.174812.
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