SARS-CoV-2中的转运体-SLC6A19

钠依赖性中性氨基酸转运蛋白B0AT1是一种由SLC6A19基因编码的蛋白质。它介导中性氨基酸通过肾和肠顶膜的上皮再吸收。最近的研究表明，血管紧张素转换酶2（ACE2）和B0AT1蛋白形成了识别SARS-CoV-2病毒的复合物，从而在冠状病毒识别和感染中发挥作用。
Key Publications：
Yan, R., Zhang, Y., Li, Y., et al. 2020. Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Science

 

Measuring SLC19A and other Transporters

SLC19A can be measured using the SSM-electrophysiology technique. It may also be measured in bilayers if reconstituted and the effect of drugs acting on transporters can be measured using impedance.

Transporter measurements

Parallel bilayer recordings

Cytotoxicity measurements