| 产品编号 | COV366 |
|---|---|
| 产品名称 | Recombinant COVID-19/SARS-CoV-2 Spike Protein 1/S1-S2 protein |
| 产品别称 | 2019-nCoV S1-S2 domain protein, COVID-19 antigen |
| 规格 | 100ug/￥2,850; 1mg/￥11,500; Bulk inquiry |
| 物种 | COVID-19/2019-nCoV |
| 宿主 | Mammalian Cells |
| 内毒素水平 | < 0.1EU per μg protein as determined by the LAL method. |
| 交叉反应 | N.A |
| 缓冲体系 | 0.01M PBS, pH7.4 |
| 纯化方式 | Ni+ Affinity & SEC-HPLC |
| 产品背景 | The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell: they are essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. The SARS-CoV spike (S) protein is composed of two subunits; the S1 subunit contains a receptor-binding domain that engages with the host cell receptor angiotensin-converting enzyme 2 and the S2 subunit mediates fusion between the viral and host cell membranes. The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity, during infection with SARS-CoV. |
| 保存条件 | Store the lyophilized powder at 4°C for one week and -20°C to -80°C for long time. Store the liquid form at -80°C. Avoid multiple freeze/thaw cycles. |
| 备注 | This product is used for research use only. Not for human or diagnostic use. |
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