A New Interface for High Sensitivity High-throughput Samples Analysis: Assessment Using the
2007-12-05441
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Introduction Rapid development of
quantitative LC-MS/MS assays for
bioanalytical application is often slowed
down by memory effects due to ion
scattering in the mass spectrometer,
following optimization by infusional
analysis at high analyste concentrations.
This can be particularly problematical for
drugs with detection limits in the sub
ng/mL range, where it may take several
hours for background levels decline to
acceptable levels. Use of high LC flow
rate can also cause high chemical
background due to inefficient desolvation,
which over time, can cause system
contamination necessitating maintenance
and interrupt the continuous operation of
the mass spectrometer that is required for
high throughput analysis. Here, we
evaluated the application and performance
a new high signal-to-noise atmospheric
pressure interface, HSID. This new
interface very effectively focuses target
analyte ions through orthogonal samp领,
such that memory effects are minimal. In
addition, it has been designed to improve
sensitivity at high LC flows by reducing
background chemical noise, through better
desolvation by using energy transfer of
heated gas as ions flow through moderate
pressure laminar flow regions of the
interface.
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