Zda限度发挥血清β淀粉酶检测在老年痴呆症的诊断中的作用

文档简介Zda限度发挥血清β淀粉酶检测在老年痴呆症的诊断中的作用NeuromolecularMed.2008;10（3）:195207.doi:10.1007/s12017-008-8035-0.MaximizingthePotentialofPlasmaAmyloid-betaasaDiagnosticBiomarkerforAlzheimer’sDiseaseEstherS.Oh,M.D.a,b*,JuanC.Troncoso,M.D.b,c,andStinaM.FangmarkTucker,Ph.D.aDepartmentofMedicine,TheJohnsHopkinsUniversitySchoolofMedicine,558RossResearchBuilding,720RutlandAve.,Baltimore,MDbDepartmentofPathology,TheJohnsHopkinsUniversitySchoolofMedicine,558RossResearchBuilding,720RutlandAve.,Baltimore,MDcDepartmentofNeurology,TheJohnsHopkinsUniversitySchoolofMedicine,558RossResearchBuilding,720RutlandAve.,Baltimore,MDAbstractAmyloidplaquesarecomposedprimarilyofamyloid-beta（Aβ）peptidesderivedfromproteolyticcleavageofamyloidprecursorprotein（APP）,andareconsideredtoplayapivotalroleinAlzheimer'sdisease（AD）pathogenesis.Presently,ADisdiagnosedaftertheonsetofclinicalmanifestations.WiththearrivalofnoveltherapeuticagentsfortreatmentofAD,thereisanurgentneedforbiomarkerstodetectearlystagesofAD.MeasurementofplasmaAβhasbeensuggestedasaninexpensiveandnon-invasivetooltodiagnoseADandtomonitorAβmodifyingtherapies.However,themajorityofcross-sectionalstudiesonplasmaAβlevelsinhumanshavenotshowndifferencesbetweenindividualswithADcomparedtocontrols.Similarly,cross-sectionalstudiesofmouseplasmaAβhaveyieldedinconsistenttrendsindifferentmousemodels.However,longitudinalstudiesappeartobemorepromisinginhumans.Recently,effortstomodifyplasmaAβlevelsusingmodulatorshaveshownsomepromise.Inthisreview,wewillsummarizethepresentdataonplasmaAβinhumansandmousemodelsofAD.WewilldiscussthepotentialofmodulatorsofAβlevelsinplasmaincludingantibodiesandinsulin,andthechallengesassociatedwithmeasuringplasmaAβ.ModulatorsofplasmaAβmayprovideanimportanttooltooptimizeplasmaAβlevels,andmayimprovethediagnosticpotentialofthisapproach.