硬骨素SOST ELISA试剂盒说明书

文档简介硬骨素SOST检测试剂盒背景介绍：标准的Wnt信号在通过提高成骨细胞,调节骨的稳定状态起着重要作用。Wnt通路的负调节因子对增强骨重吸收的疾病ZL是重要的新的ZL目标。其中一种就是硬骨素，分子量是22.5kD的分泌糖蛋白，通过与Wnt-共受体LRP5的结合而防止与Wnt分子的结合。硬骨素几乎都是在骨细胞中产生的。因此认为是提供骨特异性Z高的临床标记物。临床应用：骨质疏松症肿瘤诱导的骨疾病风湿性关节炎慢性炎症肾病合成代谢ZL监测参考文献：GaudioAetal.:IncreasedSclerostinSerumLevelsAssociatedwithBoneFormationandResorptionMarkersinPatientswithImmobilization-InducedBoneLoss.JClinEndocrinolMetab(2010),95:22482253.MirzaFetal.:SerumSclerostinLevelsNegativelyCorrelatewithParathyroidHormoneLevelsandFreeEstrogenIndexinPostmenopausalWomen.JClinEndocrinolMetab(2010),95:1991-1997.AnastasilakisDetal.:ComparativeEffectofZoledronicAcidVersusDenosumabonSerumSclerostinandDickkopf-1LevelsofNavePostmenopausalWomenWithLowBoneMass:ARandomized,Head-to-headClinicalTrial.JClinEndocrinolMetab(2013),98:3206-3212.网址：www.craymeibio.com