DKK-1 ELISA试剂盒说明书

文档简介Wnt通路YZ因子DKK-1检测试剂盒背景介绍：DKK-1是影响成骨细胞成熟的WNT信号通道的拮抗剂。Dkk-1首先在人肝母细胞瘤和Wilms’瘤中，然后在肝肿瘤中被发现高表达。Dkk-1的高表达被证明可以成为多种肿瘤预后差的标志，如肝细胞癌、食道癌、骨肉瘤、肺癌、结肠癌、骨关节炎、骨质疏松症、卵巢上皮癌和多发性瘤。DKK-1对肿瘤的骨转移有促进作用，这与DKK-1能导致骨吸收，YZ骨形成的作用相一致。产品优势：用于人血清样本检测样本量小，只需20ul检测范围宽夹心法检测操作时间短参考文献：TheroleofDickkopf-1inbonedevelopment,homeostasis,anddisease.PinzoneJJetal.,Blood,2009;113:517-525.ElevatedSerumDickopf-1LevelsIncreaseRiskofHipandVertebralFractureinOlderCaucasianWomen.ArasuAetal.,EndocrRev,2013;34:SAT-224.ComparativeEffectofZoledronicAcidVersusDenosumabonSerumSclerostinandDickkopf-1LevelsofNaivePostmenopausalWomenWithLowBoneMass:ARandomized,Head-to-HeadClinicalTrial.AnastasilakisADetal.,JClinEndocrinolMetab,2013;98:3206-3212.