Anti-CD4 antibody [mAb51312]抗体说明书

文档简介ProductoverviewDescriptionMousemonoclonal[mAb51312]toCD4HostspeciesMouseTestedapplicationsIHC-P,WB,IHC-FrCrossreactivityReactswithMouse,HumanImmunogenSyntheticpeptideconjugatedtoKLHderivedfromwithinresidues50-150ofHumanCD4.（Note:theaminoacidsequenceisproprietary）（Peptideavailableasab54699.）PositivecontrolThisantibodygaveapositivesignalinHumanThymusandHumanLymphNodeTissueLysateTargetFunctionAccessoryproteinforMHCclass-IIantigen/T-cellreceptorinteraction.MayregulateT-cellactivation.Inducestheaggregationoflipidrafts.SequencesimilaritiesContains3Ig-likeC2-type（immunoglobulin-like）domains.Contains1Ig-likeV-type（immunoglobulin-like）domain.Post-translationalmodificationsPalmitoylationandassociationwithLCKcontributetotheenrichmentofCD4inlipidrafts.CellularlocalizationCellmembrane.Localizestolipidrafts.RemovedfromplasmamembranebyHIV-1Nefproteinthatincreasesclathrin-dependentendocytosisofthisantigentotargetittolysosomaldegradation.Cellsurfaceexpressionisalsodown-modulatedbyHIV-1Envelopepolyproteingp160thatinteractswith,andsequestersCD4intheendoplasmicreticulum.Targetinformationabovefrom:UniProtaccessionP01730TheUniProtConsortiumTheUniversalProteinResource（UniProt）in2010NucleicAcidsRes.38:D142-D148（2010）.AlternativenamesCD4antibodyCD4（L3T4）antibodyCD4antibodyCD4antibodyCD4antigen（p55）antibodyCD4AntigenantibodyCD4moleculeantibodyCD4ReceptorantibodyCD4+Lymphocytedeficiency,includedantibodyCD4_HUMANantibodyCD4mutantibodyL3T4antibodyLeu3antibodyLy-4antibodyLymphocyteantigenCD4antibodyMGC165891antibodyOTTHUMP00000238897antibodyp55antibodyTCellAntigenT4antibodyTcellantigenT4/LEU3antibodyTcelldifferentiationantigenL3T4antibodyTcellOKT4deficiency,includedantibodyhttp://www.abcam.com/CD4-antibody-mAb51312-ab51312.htmlUKoffice:Abcamplc330CambridgeScienceParkCambridgeCB40FLUKTel:+44（0）1223696000Fax:+44（0）1223215215Email:orders@abcam.comUSoffice:AbcamInc.1KendallSquare,SuiteB2304Cambridge,MA02139-1517USATel:（888）77-ABCAM（22226）Fax:（877）774-8286ThesenumbersaretollfreeintheUS/CanadaEmail:us.orders@abcam.comLastupdatedonAugust24,2012TcellsurfaceantigenT4/Leu3antibodyTcellsurfaceantigenT4/Leu3antibodyTCellSurfaceAntigenT4/Leu3antibodyTCellSurfaceGlycoproteinCD4antibodyT-cellsurfaceantigenT4/Leu-3antibodyT-cellsurfaceglycoproteinCD4antibodyW3/25antibodyW3/25antigenantibodyPropertiesFormLiquidStorageinstructionsStoreat+4°Cshortterm（1-2weeks）.Aliquotandstoreat-20°Cor-80°C.Avoidrepeatedfreeze/thawcycles.StoragebufferPreservative:0.02%SodiumAzideConstituents:PBS,pH7.4SeethewebsiteformoreSDSinformationforthisproduct.PurityProteinGpurifiedClonalityMonoclonalClonenumbermAb51312IsotypeIgG1LightchaintypekappaApplicationsIHC-PIHC-P:1/50.WBWB:Useaconcentrationof1-5μg/ml.Detectsabandofapproximately55kDa（predictedmolecularweight:51kDa）.IHC-FrIHC-Fr:Useatanassaydependentconcentration.PubMed:21690251Images（Seethewebsiteforhigherresolutionimagesofthisproduct）OurAbpromisetoyou:QualityguaranteedandexperttechnicalsupportIftheproductdoesnotperformasdescribedonthisdatasheet,wewillofferarefundorreplacement.ForfulldetailsoftheAbpromise,pleasevisithttp://www.abcam.com/abpromiseorcontactourtechnicalteam.