Anti-HLA-B27 （EP-4）

文档简介Anti-HLA-B27（EP-4）CatalogNumber:DZ77217Quantitysize:0.1ml（dilutewithpH7.40.01MPBSorantibodydiluent）Background:Majorhistocompatibilitycomplex（MHC）moleculesformanintegralpartoftheimmuneresponsesystem.Theyarecell-surfacereceptorsthatbindpep-tidesandpresentthemtoTlymphocytes.Humanleukocyteantigens（HLAs）arepolymorphicmembersoftheMHCfamilythatarespecificallyinvolvedinthepresentationofantigenstotheTcellreceptor.TherearetwoclassesofHLAantigens:classI（HLA-A,HLA-BandHLA-C）andclassII（HLA-D）.ClassImoleculesareexpressedinnearlyallcellsandplayacentralroleintheimmunesystembypresentingpeptidesderivedfromtheendoplasmicreticu-lum.ThedifferentialstructuralpropertiesofMHCclassIandclassIImole-culesaccountfortheirrespectiverolesinactivatingdifferentpopulationsofTlymphocytes.HLA-Bencodesamembraneanchoredheavychainwhichhetero-dimerizeswithalightchain.Specificity:Anti-HLA-B27（EP-4）anti-HLA-B27isamousepolyclonalantibodyunconjugatedspecificforHLA-B27antibodyofhumanepitopemappingneartheaminoterminusofHLA-B27antigenofhumanuseforwesternblotting,elisa,immunoprecipitationandimmunohistochemistryProteinAaffinitychromatographypurification,purity:>95%Isotype:IgMmolwt:38kDaApplication:Westernblotting1:100-500Immunohistochemistry1:100-500ELISA1:500-1000Optimalworkingdilutionsmustbedeterminedbytheenduser.Storage:Anti-HLA-B27（EP-4）Storeat-20℃foroneyear.Avoidrepeatedfreeze/thawcycles.Thelyophilizedantibodyisstableatroomtemperatureforatleastonemonthandforgreaterthanayearwhenkeptat-20℃.WhenreconstitutedinsterilepH7.40.01MPBSordiluentofantibody,theantibodyisstableforatleastsixweeksat2-4℃.ImportantNote:Thisproductassuppliedisintendedforresearchuseonly,notforuseinhuman,therapeuticordiagnosticapplications.