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Recombinant Human anti-COVID-19/SARS-CoV-2 S1 RBD

卡梅德生物科技（天津）有限公司

企业性质生产商

入驻年限第6年

营业执照已审核
同类产品抗体(58件)

产品编号MAV102
产品名称Recombinant Human anti-COVID-19/SARS-CoV-2 S1 RBD Monoclonal Antibody
抗体亚型IgG1
克隆号7H6
规格与价格100ul/￥2,300; 500ul/￥6,500; 1000ul/￥11,000
产品别称SARS-CoV-2 RBD antibody, 2019-nCoV, Coronavirus
规格100ul/￥2,300
物种COVID-19
宿主Human
产品应用ELISA, Colloidal Gold, POCT, Neutralizaiton , Standard Positive Control
内毒素水平<0.1EU/ug determided by LAL method.
交叉反应React with SARS-CoV-2(COVID-19) S1-RBD protein. Do not react with other SARS-CoV-2 subunits.
缓冲体系0.01M PBS, pH 7.4
免疫原Native virus
产品背景A novel severe acute respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2) recently emerged and is rapidly spreading in humans, causing COVID-19. A key to tackling this pandemic is to understand the receptor recognition mechanism of the virus, which regulates its infectivity, pathogenesis and host range. SARS-CoV-2 and SARS-CoV recognize the same receptor—angiotensin-converting enzyme 2 (ACE2)—in humans. Researchers determined the crystal structure of the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2 (engineered to facilitate crystallization) in complex with ACE2. In comparison with the SARS-CoV RBD, an ACE2-binding ridge in SARS-CoV-2 RBD has a more compact conformation; moreover, several residue changes in the SARS-CoV-2 RBD stabilize two virus-binding hotspots at the RBD–ACE2 interface. These structural features of SARS-CoV-2 RBD increase its ACE2-binding affinity. Additionally, we show that RaTG13, a bat coronavirus that is closely related to SARS-CoV-2, also uses human ACE2 as its receptor.
保存条件This product can be stored at 2℃-8℃ for one month. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles.
备注This product is used for research use only. Not for human or diagnostic use.