药物筛选系统 FDSS7000EX

● 细胞内钙离子

● 膜电位

● 离子通道

● 水母发光

● FRET

● 悬浮细胞

◇ 测量实例：细胞内钙离子
使用水母发光蛋白，Fluo-3和Fura-2受体表达细胞比较钙迁移率。

适配器
可配备各种分配头

● 可选择96-，384-或1536-的分配头。 型号是可以交换的。

● 支持384和1536针脚头。

● 主机配备自动加载功能。

● 标准情况下，可以分配三种类型的化合物。 如果使用背板加载线，最多可以分配四种类型的化合物。

● 用户可以容易地更换分配头。

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清洗单元

配备各种洗涤功能

● 最多支持三种溶剂，无需携带即可进行清洗。

● 在测量过程中可以提示清洗。

● 提供超声清洗功能。

● 配备擦拭阶段以干燥。

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板堆积单元
板堆积功能适用于20或50个板

●  使用平板堆叠器，即使不使用机器人也可以进行自动测量。

● 您可以选择20个板或50个板。

● 堆叠器盒式方法可以轻松设置印版。

● 可配备条形码阅读器。

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板震动功能
板振动提供稳定的响应检测。

● 可以在对整个板施加精细振动的同时进行测量。

● 细胞和试剂可以有效且快速地混合。

●  这对于使用悬浮细胞的测定也是有效的。

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荧光/发光传感器，荧光光学
使用单个传感器支持荧光测定和发光测定

●  该传感器的荧光检测灵敏度远远超过传统荧光传感器。

●  因为可以降低激发光，所以可以降低购买激发光源的成本。
    

●  除了高灵敏度，FDSS7000EX还具有高动态范围。
    

●  荧光变换器使FRET测量成为可能。

使用氙灯和滤光片组合（多次激发和发射）的各种分析

●  通过落射照明光学系统实现良好的波长分离
  

●  Fura-2测定双激发（340 nm和380 nm）
    

●  具有发射滤光片更换器的FRET（C / Y，膜电位）
    

●  2个二向色镜和4个发射滤光片槽，用于各种分析
    

●  带有瓦数选项的白光氙灯（150 W，300 W，600 W）
    

●  6个过滤槽用于激励
    

●  均匀的板照明

FDSS Application Note No.1 Chloride ion sensitive fluorescent dye for Drug Screening [70 KB/PDF]

FDSS Application Note No.4 FDSS Cell dispensing unit for Aequorin Flash luminescence [454 KB/PDF]

FDSS Application Note No.5 COX flash luminescence screening [39 KB/PDF]

FDSS Application Note No.7 Multiplexing Calcium Mobilization and Membrane Potential Assays Using the FDSS6000 [373 KB/PDF]

FDSS Application Note No.9 Effect of Plate Mixing, Fluid Addition Height and Speed on Reducing Addition Artifacts and Negative Control Drift Using the FDSS6000 [52 KB/PDF]

FDSS Application Note No.10 Comparison of Orthogonal Technologies to Confirm Agonist Hits Generated Using the FDSS6000 [69 KB/PDF]

FDSS Application Note No.12 Fluorescence Quenching in Cell-Based Assays Can Be Dye Specific: A Case Study Using Both Fura-2 AM and Fluo-4 AM Calcium Reporter Dyes Using the FDSS6000 [204 KB/PDF]

FDSS Application Note No.13 Incorporating Cell Viability Assays into High Throughput Screening Using the FDSS6000 [39 KB/PDF]

FDSS Application Note No.15 Exposing cells to a single pulse of light of user-defined wavelength and duration using the FDSS6000 [180 KB/PDF]

FDSS Application Note No.19 Fast kinetics enzyme assay High-throughput screening of prolyl isomerase inhibitors [95 KB/PDF]

FDSS Application Note No.21 Cell-based fluorescent assay for selectivity evaluation between two Na+ channels subtypes [243 KB/PDF]

FDSS Option 1: 1536-Well Format Option with Disposable Tips and Pin Tool Head [233 KB/PDF]

FDSS Application Note No.2 CoroNa Red as a potential probe for intracellular sodium imaging [53 KB/PDF]

FDSS Application Note No.3 FRET-based Voltage Sensor dyes for Drug Screening [62 KB/PDF]

FDSS Application Note No.6 Direct comparison of Fast response and Slow response Membrane potential dye using the FDSS6000 [157 KB/PDF]

FDSS Application Note No.8 Comparison of No Wash Reagent Kits on the FDSS6000 [411 KB/PDF]

FDSS Application Note No.11 Detection and Modulation of Cardiomyocyte Calcium Oscillations Using the FDSS6000 [87 KB/PDF]

FDSS Application Note No.14 Evaluation of a new intracellular calcium fluorescent reagent using the FDSS6000 [462 KB/PDF]

FDSS Application Note No.16 FluxORTM Differentially Identifies K+ Channel Antagonists Using FDSS6000 [160 KB/PDF]

FDSS Application Note No.17 Use of Ca2+ oscillations in primary neuron culture: a new HTS model for neuronal diseases [405 KB/PDF]

FDSS Application Note No.18 β-arrestin recruitment for GPCR Screening [137 KB/PDF]

FDSS Application Note No.23 BRET1-assay using the FDSS/μCELL imaging plate reader [113 KB/PDF]

FDSS Application Note No.24 Evaluation of membrane potential assay kit using the FDSS/μCELL imaging plate reader: Detection ion channel in nicotinic acetylcholine receptors (nAChRs) [165 KB/PDF]

FDSS Application Note No.25 Identification of small molecule modulators of reactive oxygen release in TNF-α primed primary human neutrophils. [176 KB/PDF]

FDSS Application Note No.26 BRET2 assay using the FDSS/μCELL: monitoring cell surface-receptor internalization [100 KB/PDF]

FDSS Application Note No.27 Kinetic Luminescent Measurement of ROS (Reactive Oxygen Species) production with ABEL Cell activation ROS kit with PHOLASIN on the FDSS/μCELL platform [231 KB/PDF]

FDSS Option 2: High Speed Acquisition Option [239 KB/PDF]