用高分辨TGA表征药品中的结构水和自由水

The amount of moisture in pharmaceutical formulations is
an important quality control parameter because it can affect
their long-term stability and ultimate effectiveness as well
as short-term processability. Techniques such as Karl
Fischer titration, moisture evolution analysis (1,2), and
thermogravimetric analysis (TGA) have been used for
determining pharmaceutical moisture levels. However,
these techniques often have trouble differentiating
between free surface water (the source of problems) and
bound water present in the chemical formulation. Q系列热重分析仪