应用微波辐射合成14-Helical-Peptides

Abstract:

We have evaluated the effects of microwave irradiation on the solid-phase synthesis of B-peptides. Sequences designed to adopt the 14-helix, especially those containing the structure promoting residue trans-2-aminocyclohexanecarboxylix acid (ACHC), suffer from poor synthetic efficiency under standard SPPS conditions. A comparision of microwave and conventional heating shows that both provide excellent synthetic results for shorter sequences; however, we identify a clear benefit from microwave irradiation for longer B-peptides.

应用微波辐射合成14-Helical-Peptides


摘要：

我们已经评估微波辐射对固相合成B-peptides的影响在标准SPPS条件下, 序列用作吸纳14-螺旋(14-Helix)是存在非常低的合成效率，尤其是那些含有trans-2-aminocyclohexanecarboxylix acid (ACHC) 残余物的结构比较微波加热和常规加热表明，两者都能为合成短序列多肽提供zhuo越的综合成果;但是，我们确定微波辐射也能够为合成较长的乙肽(-Peptides) 提供zhuo越的综合成果

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