药物杂质分析：甲氧氯普安杂质

In the modern pharmaceutical industry,
it is critically important to identify and
quantify impurities with the highest
possible confidence given their potential
toxic effects on humans. This report
describes the performance of the
Agilent 6545 Q
-
TOF LC/MS system in
the determination of metoclopramide
pharmaceutical impurities.
In this, the 6545 Q
-
TOF and 1290
Infinity LC system are used to
determine metoclo
pramide impurities
(structures below).
Metoclopramide standard prepared at 500
ppm was spiked with all known impurities
described in European Pharmacopoeia and
two additional impurities at 0.05% (w/w)
and 0.01% (w/w) levels. Agilent 6545 四极杆飞行时间液质联用系统