冷冻研磨机-研究乳化配方性質受低温研磨影响

Abstract


Recently, self-emulsifying drug delivery systems (SEDDS) have been developed as a method to deliver lipophilic drugs.
Gelucire® 44/14 is an excipient, from the lauroyl macrogolglycerides family, producing a fine oil-in-water emulsion when
introduced into an aqueous phase under gentle agitation as SEDDS, improving thereby solubility of poorly water-soluble drugs
and their bioavailability. The aims of this study were to process Gelucire® 44/14 into a powder by cryogenic grinding to produce
solid oral dosage forms and to investigate influence of this process on different properties of a formulation made of Gelucire®
44/14 and ketoprofen (90/10). Cryogenic grinding produced Gelucire® 44/14 in a powder form and this process did not change
its physical properties, emulsification capacities and dissolution performances of the formulation tested. However, interactions
took place between ketoprofen and Gelucire® 44/14 with a decrease of the melting peak and a reduction of the droplet size of
the formed emulsion. The influence of drugGelucire® 44/14 interactions must be investigated case by case in any formulations.
© 2004 Elsevier B.V. All rights reserved.
Keywords: Lipid formulations; Self-emulsifying systems; Gelucire® 44/14; Ketoprofen; Bioavailability; Cryogenic grinding SPEX6770 全自动冷冻研磨机 SPEX6870 全自动冷冻研磨机 SPEX6970EFM 冷冻研磨机