Graphene oxide

We have investigated the interaction between
graphene oxide and lipid membranes, using both supported
lipid membranes and supported liposomes. Also, the reverse
situation, where a surface coated with graphene oxide was
exposed to liposomes in solution, was studied. We discovered
graphene oxide-induced rupture of preadsorbed liposomes and
the formation of a nanocomposite, bio-nonbio multilayer
structure, consisting of alternating graphene oxide monolayers
and lipid membranes. The assembly process was monitored in
real time by two complementary surface analytical techniques (the quartz crystal microbalance with dissipation monitoring
technique (QCM-D) and dual polarization interferometry (DPI)), and the formed structures were imaged with atomic force
microscopy (AFM). From a basic science point of view, the results point toward the importance of electrostatic interactions
between graphene oxide and lipid headgroups. Implications from a more practical point of view concern structure−activity
relationship for biological health/safety aspects of graphene oxide and the potential of the nanocomposite, multilayer structure as
scaffolds for advanced biomolecular functions and sensing applications. Q-Sense全自动八通道石英晶体微天平